Non-League Sutton United will entertain 12-time winners Arsenal after the Emirates FA Cup fifth round draw was made on Monday evening.
Paul Doswell's side edged Leeds United in round four and were rewarded with a glamour tie at Gander Green Lane.
Lincoln City, the only other National League side left in the competition, will travel to Premier League outfit Burnley.
There is a London derby between Fulham and Tottenham Hotspur while holders Manchester United face Blackburn Rovers.
The last-16 ties will be played across the weekend of Saturday 18 February, with the winning clubs receiving £180,000 from The FA prize fund.
Fifth Round draw:
Burnley v Lincoln City
Fulham v Tottenham Hotspur
Blackburn Rovers v Manchester United
Sutton United v Arsenal
Middlesbrough v Oxford United
Wolverhampton Wanderers v Chelsea
Huddersfield Town v Manchester City
Millwall v Leicester City