Dan Micciche will be taking charge of the Young Lions this season and their first match takes place on Sunday 16 August.
The nations will meet again three days later on Wednesday 19 August in the first of what will be a new programme for the U16s following the decision to withdraw from the Victory Shield earlier this year.
Head coach Micciche has selected a 20-man group for the games, having worked with the players previously during their training camps with the U15s last term.
Goalkeepers: Harrison Male (Leeds United), Alex Cull (Southampton)
Defenders: Marc Guehi (Chelsea), Marcel Lavinier (Chelsea), Ryan Sessegnon (Fulham), Alex Cochrane (Brighton & Hove Albion), Zech Medley (Chelsea), Johnathan Panzo (Chelsea), Adao Manuel (Manchester City), Kane Wilson (West Bromwich Albion)
Midfielders: Ethan Ampadu (Exeter City), Matt O’Riley (Fulham), George McEachran (Chelsea), Angel Gomes (Manchester United), Emile Smith Rowe (Arsenal), Ian Carlo Poveda (Brentford), Danny Loader (Reading), Theo Hudson (Leeds United)
Forwards: Jamie Soule (West Bromwich Albion), Austin Samuels (Wolverhampton Wanderers)