England take on Uruguay in Sao Paulo on Thursday in Sao Paulo in the second Group D match at the FIFA World Cup.
As both sides suffered defeat in their opening games, the pressure is on and a memorable evening in Brazil awaits.
To whet the appetite ahead of Thursday's clash, we look back on five of the pair's previous meetings - including their most recent encounter at Anfield back in 2006 and an uninspiring start to the Three Lions' glorious 1966 campaign...
The first meeting
Uruguay 2 England 1, May 31 1953
In a game featuring future World Cup winning manager Alf Ramsey, England's first meeting with Uruguay ended in defeat in Montevideo.
A stomach bug swept the squad just before the match in the Uruguayan capital, which may have affected England's performance against the reigning world champions.
Around 80,000 fans packed into the Centenary Stadium to watch Uruguay take a two-goal lead through Julio Cesar Abbadie and Omar Oscar Miguez . Tommy Taylor restored some pride for England in the final minute but it was not enough and Walter Winterbottom's side went down 2-1.
Lineup: Merrick, Ramsey, Eckersley, Wright (C), Johnston, Dickinson, Berry, Lofthouse, Finney, Taylor, Broadis.
Manager: Walter Winterbottom
Defeat in Basel
Uruguay 4 England 2, June 26 1954
A year after their first meeting, England and Uruguay met again at the 1954 World Cup in Switzerland.
In the heat of the St Jakob Stadium in Basel, Carlos Borges put Uruguay in front.
Nat Lofthouse soon brought England level, but Obdulio Jacinto Varela and Juan Alberto Schiaffino gave Uruguay a 3-1 lead.
Sir Tom Finney pulled one back for England. The Three Lions' hopes of a semi-final place were dashed when Javier Ambrois scored Uruguay's fourth.
Lineup: Merrick, Byrne, Staniforth, Wright (C), Dickinson, McGarry, Matthews, Lofthouse, Finney, Broadis, Wilshaw.
Manager: Walter Winterbottom
1966 World Cup gets under way
England 0 Uruguay 0, July 11 1966
Generations of fans will always look back on the 1966 with the fondest of memories - while many younger supporters dream of that perfect summer being repeated during their lifetime.
However, few would have predicted England would go on to win the World Cup after this uninspiring start.
Uruguay came to England determined to prevent their hosts getting off to a winning start. In modern day terms it could be said they parked the bus - and did so with great success.
A team containing the illustrious attacking talents of Bobby Charlton, Jimmy Greaves and Roger Hunt were unable to break down a determined Uruguay back-line and the game ended goalless.
The closest England came to scoring was in the last minute when Manchester United outside forward John Connelly back-heeled the ball inches wide of the Uruguay goal.
Lineup: Banks, Cohen, Wilson, Charlton, Moore (c), Stiles, Ball, Charlton, Greaves, Connelly, Hunt.
Manager: Alf Ramsey
Italia 90 preparation
England 1 Uruguay 2, May 22 1990
England failed to give their fans a good send off in their final home fixture before Italia '90.
Santiago Ostolaza put Uruguay ahead before John Barnes equalised with an impressive strike, but Jose Batlle Perdomo gave Uruguay the win just after the hour.
Uruguay warmed up for the match with a bizarre friendly against Wandsworth Police Station at Roehampton. Surprisingly, the score was only 3-1 to Uruguay.
Lineup: Shilton, Parker, Pearce, Walker, Butcher, Waddle, Hodge, Gascoigne, Robson (C), Barnes, Lineker.
Manager: Bobby Robson
Joe Cole shines at Anfield
England 2 Uruguay 1, March 1 2006
Three months before the World Cup in Germany, England recorded a morale-boosting win thanks to Joe Cole's man-of-the-match performance.
Playing at Anfield as Wembley was being rebuilt at the time, England got off to a poor start when Omar Pouso put Uruguay ahead with a 30-yard volley.
After the break Cole set up Peter Crouch for England's equaliser and the then Chelsea man grabbed the winner in added time when he converted Shaun Wright-Phillips' cross.
Current squad members Diego Forlan, Diego Lugano, Diego Godin, Diego Perez and Alvaro Pereira all featured in the match on Merseyside.
Lineup: Robinson, Neville, Terry, Ferdinand, Bridge, J Cole, Gerrard, Beckham (C), Carrick, Rooney, Bent.
Manager: Sven-Goran Eriksson