The former Chelsea teammates will hope to guide the Wiltshire club to an instant return to League One following their relegation last season.
The influence of Wise, who guided Millwall to the FA Cup Final three years ago when in charge at the New Den, makes Swindon one of the pre-season favourites.
League Two is a notoriously tough league to get out of and Swindon, along with other relegated clubs Hartlepool, MK Dons and Walsall, will not be in for an easy ride.
MK Dons have brought in former Brentford manager Martin Allen to the National Hockey Stadium.
His reputation will be important to the once Premiership team who will be hoping they can steady the ship after a difficult few years.
Richard Money at Walsall and Danny Wilson at Hartlepool are both new managers at clubs with fans hoping for successful league campaigns.
The new boys to League Two - Accrington Stanley and Hereford - will hope the jump from the Conference will be a fruitful one and will take inspiration from the likes of Carlisle, Yeovil and Doncaster who have all earned double promotions over the past few years.
It's a welcome return for Accrington Stanley who end a 44-year footballing exile from league football.
Manager John Coleman will be hoping they can hold their own along with Graham Turner's Hereford who came up through the Conference play-offs.
Last season's play-off final losers Grimsby may have changed management but they will be expected to challenge along with Lincoln who have reached the play off stages for the past four seasons.
Bristol Rovers and Notts County are perennial underachievers in League Two and will be looking for better campaigns this time around.
Wycombe went unbeaten under John Gorman until Christmas last season and looked on course for promotion.
But a disastrous second half of the season saw them fall at the final hurdle.
But with former Scotland international Paul Lambert now in charge at Adams Park they could be an outside bet for promotion.
At the bottom Torquay and Stockport will hope they keep away from the relegation trapdoor after a poor season last time around.
Ian Atkins did a miraculous job at Torquay last year to keep them up and with a full season in charge this time, they may be a surprise package.
Log on tomorrow as we check out League One.