Wayne Rooney and Theo Walcott both pick up knocks in action on Saturday
limped out of Manchester United's 3-2 win at Villa Park on Saturday with ankle injury.
United came from two goals down to beat Aston Villa, thanks to Javier Hernandez's second-half hat-trick.
But with England travelling to Sweden for Wednesday's friendly
, the injury to Rooney, which saw him taken off with 12 minutes left, will concern Roy Hodgson.
And United boss Sir Alex Ferguson says the 27-year-old will be assessed on Sunday.
"Rooney got an ankle knock and he's got some ice on it," he told Sky Sports. "We'll see what it's like tomorrow."
Ashley Young endured a disappointing return to Villa Park and was replaced at the break by Mexican Hernandez.
Rio Ferdinand, Michael Carrick, Chris Smalling and Tom Cleverley also featured.
Theo Walcott also picked up an injury during an impressive performance for Arsenal as they drew 3-3 at home to Fulham.
It was his excellent chip that found Olivier Giroud, who equalised for Arsene Wenger's side to grab a point.
Walcott was replaced with six minutes left after suffering the problem during the first half.
Manager Arsene Wenger revealed the forward would need to be assessed ahead of next Wednesday's England match.
"Walcott has a glute muscle problem," said Wenger.
"We nearly took him off at half-time, he nearly went down, but we left him on and on.
"In the end, it got worse and worse. At the moment, he is limping so I do not know whether he will be able to join the national team or not."
In Stoke, Ryan Shawcross
celebrated his call-up to the England squad with another commanding performance as the Potters beat Queens Park Rangers 1-0 at Britannia Stadium.
Shawcross is part of a Stoke side that has conceded just one goal at home in the league all season - the best record in England - and he turned in another fine performance.
Leon Osman, who could get his first England cap on Wednesday, and his fellow international team-mate Leighton Baines were part of an Everton side that came from behind to beat Sunderland 2-1. Adam Johnson netted the opener for Sunderland.
Elsewhere, goalkeeper John Ruddy kept a clean sheet as Norwich claimed a goalless draw at Reading while, in the Championship, England Under-21s stars Tom Ince and Nathan Delfouneso both netted as Blackpool drew 2-2 with Bolton Wanderers.
Though Delfouneso is not involved in this week's international action, Ince will be eyeing another goal at Bloomfield Road on Tuesday night, when Stuart Pearce's side meet Northern Ireland
Derby County's Will Hughes marked his first Under-21s call-up with a goal against Millwall but it wasn't enough to stop the Rams going down 2-1 at the Den.