Conor Coady and Marcus Rashford will miss England’s remaining November internationals.
Coady has been forced to self-isolate having discovered he had inadvertently come into contact with somebody prior to camp who has tested positive for COVID-19 via an NHS Test and Trace alert.
The Wolverhampton Wanderers defender had returned two negative tests as part of The FA and UEFA’s protocol but, in line with UK Government guidelines, has to adhere to a period of self-isolation.
Meanwhile, Rashford’s arrival into camp had initially been delayed to allow for further assessment on an injury sustained last weekend but the Manchester United forward will now not meet up.
The duo both missed the Three Lions' 3-0 win over the Republic of Ireland at Wembley Stadium connected by EE on Thursday evening. Next up is a trip to face Belgium in Leuven on Sunday, ahead of next Wednesday's home clash with Iceland.
Updated England squad to face Belgium and Iceland
Tammy Abraham (Chelsea), Jude Bellingham (Borussia Dortmund), Dominic Calvert-Lewin (Everton), Ben Chilwell (Chelsea), Eric Dier (Tottenham Hotspur), Phil Foden (Manchester City), Jack Grealish (Aston Villa) Dean Henderson (Manchester United), Jordan Henderson (Liverpool), Reece James (Chelsea) Harry Kane (Tottenham Hotspur), Michael Keane (Everton), Harry Maguire (Manchester United), Ainsley Maitland-Niles (Arsenal), Tyrone Mings (Aston Villa), Mason Mount (Chelsea), Jordan Pickford (Everton), Nick Pope (Burnley), Declan Rice (West Ham United), Bukayo Saka (Arsenal) Jadon Sancho (Borussia Dortmund), Raheem Sterling (Manchester City), Kieran Trippier (Atletico Madrid), Kyle Walker (Manchester City), Harry Winks (Tottenham Hotspur)