They struggled in qualifying and finished below Serbia and Montenegro in their group, before beating Slovakia in a play-off.
Star striker Raul was a doubt for the tournament after suffering serious knee ligament damage but he is back and in the squad.
However, there are also plenty of other options with Fernando Torres, David Villa and Jose Antonio Reyes all available as well.
This will be Spain's eighth successive appearance in the World Cup Finals - ironically the last time they missed out was when the 1974 tournament was held in Germany.
Coach: Luis Aragones
One to watch: Fernando Torres
World ranking: 5
Previous tournaments: 11
Best finish: Fourth place (1950)